A.   The repolarization phase of the action potential

B.   The depolarization phase of the action potential

C.   All of these will not occur

D.   The graded potential

E.   The exocytosis of neurotransmitter

A.   Myosin is the main regulatory protein in smooth muscle.

B.   Only skeletal muscle has both actin and myosin.

C.   Only skeletal muscle requires increased calcium ion concentration in the cytosol for contraction.

D.   Skeletal muscle usually exhibits spontaneous activity, while smooth muscle cannot contract spontaneously. 

E.   Myosin is the main regulatory protein in skeletal muscle.

A.   Calcium-induced calcium release plays a role in cardiac muscle cells, as well as in some smooth muscle cells.

B.   In all kinds of muscle it requires the entry of calcium from the extracellular fluid.

C.     

D.   In smooth muscle cells, it must be preceded by an action potential in the cell membrane.

E.   In skeletal muscle cells, excitation-contraction coupling begins when an action potential propagates along the sarcoplasmic reticulum membrane.

F.   In skeletal muscle cells, it requires the influx of extracellular calcium ion.

A.   A single action potential in the motor neuron causes a sustained contraction.

B.   The action potential in the muscle cell is prolonged to last as long as the contraction.

C.   A very large amplitude action potential in the motor neuron causes a very strong contraction in the skeletal muscle cell.

D.   Multiple action potentials in the motor neuron cause a sustained contraction.

E.   Repeated action potentials from the motor neuron summate into a sustained depolarization of the motor end plate, causing a sustained contraction.

A.   Changes in cytosolic calcium do not regulate cross-bridge activity in smooth muscle.

B.   The myosin in smooth muscle requires phosphorylation before it can bind to ATP.

C.   Smooth muscle is striated.

D.   Smooth muscle does not use troponin-tropomyosin to regulate cross-bridge activity.

E.   Smooth muscle does not have thick and thin filaments.

A.   All muscles of the body might present a tense, fully contracted state.

B.    All muscles of the body might exhibit frequent small twitches.

C.   All muscles of the body will be completely normal in function.

D.   All muscles of the body might present a limp, relaxed state known as flaccid paralysis.

A.   Muscle relaxation

B.   Drowsiness

C.     

D.   None of the answer choices are correct

E.   Muscle cell twitches (contractions)

F.   Muscle paralysis

A.   You will experience the visual sensation before the pain sensation.

B.   Both sensations will occur at the same time.

C.   It depends on the magnitude of the pain sensation, it may reach the brain first or second.

D.   You will feel the pain sensation before the visual sensation.

A.   By the duration of action potentials

B.   By the size of action potentials

C.   By the frequency of action potentials

D.   By whether the action potential peak is positive or negative

A.   Gamma-aminobutyric acid (GABA)

B.   Norepinephrine

C.   Beta-endorphin

D.   Glutamate

E.   Dopamine

A.   Calcium ion influx through sarcolemma, calcium release into cytosol, actin and myosin attach, thin myofilaments slide toward the middle of sarcomeres

B.   Calcium release into cytosol, actin and myosin attach, thin filaments slide toward the middle of sarcomeres, calcium ion influx through sarcolemma

C.   Actin and myosin attach, thin filaments slide toward the middle of sarcomeres, calcium release into cytosol

D.   Calcium release into cytosol, calcium ion influx through sarcolemma, actin and myosin attach, thin filaments slide toward the middle of sarcomeres

E.   Calcium release into cytosol, actin and myosin attach, calcium ion influx through sarcolemma, thin myofilaments slide toward the middle of sarcomeres

A.   The plasma membrane is completely impermeable to potassium ions.

B.   The permeability of the plasma membrane to potassium ions is much greater than its permeability to sodium ions.

C.   The plasma membrane is most permeable to sodium ions.

D.   The concentration of sodium ion is greater inside the cell than outside.

E.   The plasma membrane is completely impermeable to sodium ions.

A.     

B.   They manufacture and store ATP.

C.   They store the calcium ions that are the main source of activation for the cross-bridge cycle.

D.   They form the Z lines that mark the end of each sarcomere.

E.   They run in parallel with the myofibrils, and have abundant Ca2+-ATPase proteins for pumping Ca2+ back into the sarcoplasmic reticulum.

F.   They allow action potentials to propagate deep into the center of skeletal muscle cells.

A.   agonist to the endogenous opioid receptors.

B.   agonist to epinephrine receptors.

C.   agonist to glycine receptors.

D.   agonist to serotonin receptors.

E.   Any of these are possible

A.   Endorphin

B.   Norepinephrine

C.   Dopamine

D.   Gamma-aminobutyric acid (GABA)

E.   Glutamate

A.   In skeletal muscle, calcium ions bind to a regulatory protein on thin filaments; in smooth muscle, calcium ions bind to a regulatory protein on thick filaments.

B.   In skeletal muscle, calcium initiates contraction by binding to troponin, while in smooth muscle calcium initiates contraction by binding directly to myosin.

C.   In skeletal muscle, calcium initiates contraction by binding to troponin, while in smooth muscle calcium initiates contraction by binding to calmodulin.

D.   In skeletal muscle, calcium initiates contraction by binding to myosin light-chain kinase, while in smooth muscle calcium initiates contraction by binding directly to tropomyosin.

A.   The permeability to Na+ is much greater than the permeability to K+.

B.   Most of the voltage-gated Na+ channels are in the closed state.

C.   The voltage-gated Na+ channels are in the inactivated state.

D.   There is equal permeability to Na+ and K+.

E.   All of the K+ channels in the membrane are open.

A.   A single twitch in skeletal muscle but no sustained contraction.

B.   Binding of myosin to actin will take place.

C.   Only one cross-bridge cycle will occur but no second cycle. 

D.   Contraction will occur, but the muscle will be stuck in the contracted state and unable to relax.

E.   Tropomyosin will continue to cover the myosin binding sites on actin and no cross-bridges will form.

A.   The relative refractory period refers to the period of time during which another action potential can be initiated in that part of the membrane that has just undergone an action potential if a stronger than normal stimulus is applied.

B.   The absolute refractory period refers to the period of time during which another action potential cannot be initiated in that part of the membrane that is undergoing an action potential, no matter how great the strength of the stimulus.

C.   The refractory period places an upper limit on the frequency with which a nerve cell can conduct action potentials.

D.   The refractory period prevents the action potential from spreading back over the part of the membrane that just underwent an action potential. The relative refractory period refers to the period of time during which another action potential can be initiated in that part of the membrane that has just undergone an action potential if a stronger than normal stimulus is applied. The refractory period places an upper limit on the frequency with which a nerve cell can conduct action potentials. The absolute refractory period refers to the period of time during which another action potential cannot be initiated in that part of the membrane that is undergoing an action potential, no matter how great the strength of the stimulus.

E.   The refractory period prevents the action potential from spreading back over the part of the membrane that just underwent an action potential.

A.   The shorter a skeletal muscle cell is when it begins to contract, the stronger the force generation will be.

B.   Skeletal muscle cells generate the most force when the contraction occurs at an intermediate length.

C.   The tension in a skeletal muscle cell is greatest when contractions occur at either very short or very long lengths.

D.   The longer a skeletal muscle cell is when it begins to contract, the stronger the force generation will be.

E.   Skeletal muscle cells generate the same amount of force, regardless of their length.

A.   Increased Na+ flux through K+ channels.

B.   increased K+ permeability of the cell.

C.   increased K+ flux into the cell.

D.   Na+ permeability that is greater than that during the depolarization phase.

E.   activation and inactivation of voltage-dependent Na+ channels.

A.   A single muscle fiber plus all of the motor neurons that innervate it

B.   All of the motor neurons supplying a single muscle

C.   All of the muscles that affect the movement of any given joint

D.   A single motor neuron plus all the muscle fibers it innervates

E.   A pair of antagonistic muscles

A.   Z is excitatory and Y is inhibitory.

B.   They are both inhibitory.

C.   Y is excitatory and Z is inhibitory.

D.   They are both excitatory.

A.   Type 2X fibers have more abundant mitochondria.

B.   Type 2X fibers are smaller in diameter.

C.   Type 2X fibers fatigue more readily.

D.   Type 2X motor units contain fewer fibers per alpha motor neuron.

E.   Type 2X fibers have more abundant myoglobin.

A.   ATP; attachment

B.   actin; detachment

C.   ATP; detachment

D.   calcium; detachment

E.   calcium; attachment

A.   an action potential is propagated without decrement, whereas a graded potential decrements with distance.

B.   an action potential has a threshold, whereas a graded potential is an all-or-none phenomenon.

C.   movement of Na+ and K+ across cell membranes mediate action potentials, while graded potentials do not involve movement of Na+ and K+.

D.   action potentials vary in size with the size of a stimulus, while graded potentials do not.

E.   an action potential requires the opening of Ca2+ channels, whereas a graded potential does not.

A.   In the absence of any neural input, skeletal muscle cannot generate tension.

B.   Ca2+ that activates contraction of smooth muscles can come from either the ECF or from the sarcoplasmic reticulum.

C.   Contractile activity of smooth muscle cells does not normally require Ca2+.

D.   A single smooth muscle cell may be innervated by both a sympathetic neuron and a parasympathetic neuron.

E.   Synaptic input onto skeletal muscle cells is always excitatory, whereas inputs to smooth muscle cells may be either excitatory or inhibitory.

A.   Muscle function is fine, but it will cause a loss of voluntary control.

B.   It will cause spastic paralysis (sustained, unwanted muscle contraction).

C.   It activates an autoimmune disease that destroys myelin.

D.   It will cause flaccid paralysis (no muscle contraction possible).

E.   It will cause persistent twitches with short periods of rest in between.

A.   tension generated by the muscle always exceeds the load on the muscle.

B.   the whole muscle shortens.

C.   sarcomeres do not significantly shorten.

D.   H zones shorten.

E.   tetanus occurs.

A.   bound to muscarinic receptors at the end plate.

B.   bound to Ca2+ ions.

C.   bound to acetylcholinesterase in the end plate membrane.

D.   inside the muscle cell sarcoplasm.

E.   bound to receptors on the sarcoplasmic reticulum.

A.   They depolarize postsynaptic cell membranes.

B.   They transmit signals over relatively short distances.

C.   They are always the same amplitude.

D.   They are able to summate.

E.   They are produced by the opening of ligand-gated sodium channels.

A.   The postsynaptic cell will undergo an IPSP.

B.   The postsynaptic cell will immediately undergo an action potential.

C.   The postsynaptic cell will undergo an EPSP.

D.   There will be no change to the membrane potential in the postsynaptic cell.

A.   Atropine (a muscarinic acetylcholine receptor antagonist)

B.   A nicotinic acetylcholine receptor antagonist

C.   A drug that inhibits release of acetylcholine

D.   A drug that inhibits acetylcholinesterase

E.   Curare

A.   Actin dissociates from myosin.

B.   Cross-bridges rotate, sliding past the thin filament.

C.   Actin binds to myosin.

D.   Cross-bridge heads are cocked into an "energized" state.

E.   Ca2+ is released from the sarcoplasmic reticulum.

A.   trigger an action potential.

B.   be conducted to the axon hillock.

C.   cause a change in membrane potential.

D.   trigger an excitatory postsynaptic potential.

A.   The order of recruitment of motor units in a muscle is such that the last units recruited are those that fatigue most readily.

B.   Recruitment of one fast-glycolytic motor unit provides a smaller increment in whole-muscle tension than recruitment of one slow-oxidative motor unit.

C.   Motor units whose motor neurons have large-diameter cell bodies are recruited first, while motor units with smaller-diameter motor neurons are only activated as the level of activation in the spinal cord increases.

D.   The order of motor unit recruitment is independent of the size of the alpha motor neuron that innervates them.

E.   The order of recruitment of motor units in a muscle is such that the first units recruited generate the most tension.

A.   They cause the absolute refractory period to be very brief.

B.   They are responsible for preventing tetanic contractions.

C.   They act as non-conducting voltage sensors that mediate excitation-contraction coupling.

D.   They function exactly the same in cardiac muscle cells as they do in skeletal muscle.

E.   They are directly responsible for making cardiac muscle fatigue-resistant.

A.   All muscle contractions after Sarah reaches fatigue (about an hour into her run)

B.   Every moment of Sarah's runs

C.   No effects on her running

D.   All muscle contractions after Sarah reaches her maximum heart rate (about 10 minutes into her run)

E.   Just the first few seconds of exercise

A.   PK+ is the same as PNa+.

B.   K+ flows rapidly into the cell.

C.   PNa+ becomes much greater than PK+.

D.   Na+ efflux (flow out of the cell) occurs.

E.   PK+ becomes much greater than PNa+.

A.   The permeability to K+ increases greatly while that to Na+ decreases.

B.   The permeability to Na+ increases greatly.

C.   Voltage-gated Na+ channels are opened.

D.   The Na+, K+ pump restores the ions to their original locations inside and outside of the cell.

E.   ATPase destroys the energy supply that was maintaining the action potential at its peak.

A.   lower concentrations of glycolytic enzymes in her leg muscles.

B.   leg muscles with a larger diameter.

C.   leg muscles with a smaller diameter.

D.   a higher density of capillaries in her leg muscles.

E.   hypertrophy of type I muscle fibers.

A.   Two synapses on different regions of a cell are stimulated at the same time.

B.   The size of an EPSP depends on the size of the stimulus.

C.   It only refers to addition of EPSPs.

D.   A synapse is stimulated a second time before the effect of a first stimulus at the synapse has terminated.

E.   It always brings a postsynaptic cell to threshold.

A.   Troponin covers the binding site on myosin molecules until Ca2+ binds to troponin to remove it from its blocking position.

B.   Myosin is an ATPase.

C.   The rate of ATP hydrolysis by myosin is the same in all types of skeletal muscle.

D.   All of the myosin cross-bridge heads in a thick filament are oriented and rotate in the same direction.

E.   Myosin cross-bridge heads contain two binding sites, one for actin and one for tropomyosin.

A.   troponin.

B.   myosin.

C.   the thick filament.

D.   tropomyosin.

E.   actin.