Chem 40005 - Clinical Chemistry » Summer 2021 » Module 6 Quiz

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Question #1
The release of thyroid-stimulating hormone (from the pituitary gland) stimulates the release of thyroid hormones from the thyroid gland. When the level of thyroid hormones increases in the circulation, they shut off the release of TSH from the pituitary. This is an example of which type of feedback?
A.   Negative feedback
B.   Positive feedback
C.   Open loop feedback
D.   None of the above
Question #2
As part of homeostatic control by hormones, the metabolism of electrolytes and water balance is controlled in part by the renal system. What hormone synthesized by the kidneys affects water and electrolyte balance?
A.   Aldosterone
B.   Renin
C.   Vasopressin; antidiuretic hormone (ADH)
D.   Insulin
Question #3
Which one of the following statements concerning steroid hormones is correct?
A.   Steroid hormones are hydrophobic when free and bind to intracellular receptors in the nucleus.
B.   Steroid hormones, because of their structure, are not bound to carrier proteins as they circulate in the blood.
C.   Steroid hormones attach to a receptor on the surface of a cell, which eventually induces enzyme phosphorylation within the cell.
D.   Steroid hormones have a very short half-life (usually <30 minutes) in the circulation.
Question #4
Which of the following protein hormones produces a decrease in blood glucose by causing glucose to enter cells for energy production?
A.   Thyroid hormone
B.   Cortisol
C.   Aldosterone
D.   Insulin
Question #5
The half-life of a protein hormone in plasma is
A.   long, usually greater than 90 minutes.
B.   short, approximately 10–30 minutes.
C.   short, more than 1 hour but less than 3 hours.
D.   long, at least 24 hours.
Question #6
Scurvy is associated with deficiency of which one of the following vitamins?
A.   B12
B.   C
C.   D
D.   A
Question #7
The most commonly used method of analysis for assessing vitamins A, K, and B6 is
A.   high-performance liquid chromatography (HPLC).
B.   spectrophotometry.
C.   competitive protein binding.
D.   immunoassay.
Question #8
Absorption of vitamin B12 requires the presence of
A.   folic acid.
B.   vitamin C.
C.   insulin.
D.   intrinsic factor.
Question #9
What is the common cause of vitamin B12 deficiency?
A.   Pernicious anemia
B.   Hyperkeratosis
C.   Rickets
D.   Scurvy
Question #10
A 10-year-old girl visits her pediatrician. The physician notes that the girl has immature secondary sex characteristics and small stature. Her mother who has accompanied her complains that the adolescent also exhibits very slow healing of cuts and scrapes and has had some hair loss. Your laboratory has ruled out any inborn error of metabolism and possible cancer. Deficiency of what trace element might be responsible for the stated symptoms?
A.   Zinc
B.   Copper
C.   Selenium
D.   Chromium
Question #11
Which vitamin is given to a newborn within minutes of birth?
A.   D
B.   B12
C.   A
D.   K
Question #12
A 65-year-old woman was admitted to the hospital in mild congestive heart failure. She complained of a burning sensation in her calves and feet and of weight loss. Upon admission she appeared confused, depressed, and pale. She had some edema around her ankles. Her lab results were as follows: low hemoglobin and hematocrit, increased RBC size, decreased RBC and WBC count, and hypersegmented neutrophils. All basic chemistry values were normal. Which vitamin should be tested for deficiency?
A.   Vitamin D
B.   Vitamin A
C.   Vitamin B12
D.   Vitamin C
Question #13
The inherited disorders caused by an underproduction of certain globin chains are referred to as the
A.   hemoglobin variant disorders.
B.   iron deficiency disorders.
C.   hemoglobinopathies.
D.   thalassemias.
Question #14
In a certain hemoglobin structural variant, a deletion in the coding gene results in a reduction of the production of the beta globin chain. This will result in
A.   a sickling disorder due to insoluble hemoglobin.
B.   an α-thalassemia due to overproduction of alpha-globin chains.
C.   decreased quantity of HbA.
D.   hemolysis of red blood cells due to unstable hemoglobin.
Question #15
Regarding serum iron analysis, the maximum concentration of iron that transferrin can bind is reflected in what laboratory measurement?
A.   Hemoglobin
B.   Serum iron
C.   Transferrin saturation
D.   Total iron-binding capacity (TIBC)
Question #16
The most common cause of iron deficiency anemia in children is
A.   megaloblastic anemia.
B.   hemolytic anemias.
C.   bleeding ulcers.
D.   dietary deficiency.
Question #17
What soluble iron-protein complex is the form in which iron is stored in tissues?
A.   Hemoglobin
B.   Hemosiderin
C.   Ferritin
D.   Transferrin
Question #18
The major substance formed from the breakdown of hemoglobin when senescent red blood cells are phagocytized by the reticuloendothelial system is
A.   urobilinogen.
B.   urobilin.
C.   myoglobin.
D.   bilirubin.
Question #19
The two pairs of globin chains in normal HbA hemoglobin are
A.   alpha and beta.
B.   beta and gamma.
C.   alpha and gamma.
D.   beta and delta.
Question #20
What is the percent transferrin saturation given the following data: serum iron 150 μg/dL, TIBC 350 μg/dL, transferrin 300 mg/dL, and ferritin 65 ng/mL?
A.   500%
B.   55%
C.   233%
D.   43%

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