Chem 40005 - Clinical Chemistry » Summer 2021 » Module 9 Quiz
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Question #1
The period of time during which the concentration of a therapeutic drug decays by 50% is referred to as the drug’s
A.
volume of distribution.
B.
subtherapeutic range.
C.
dosing curve.
D.
half-life.
Question #2
If a drug is acidic in nature, which of the following proteins will it associate with primarily for transport and distribution?
A.
Albumin
B.
Lipoprotein
C.
Albumin, Lipoprotein, and α1-Glycoprotein
D.
α1-Glycoprotein
Question #3
Which of the following could account for drug toxicity following a prescribed dose?
A.
Using a single drug as opposed to multiple drugs for treatment
B.
Decreased renal elimination leading to increased free drug concentration
C.
Increased drug metabolism caused by central nervous system disease
D.
Using a different route of administration than is typically used for that drug
Question #4
Which one of the following is not a good rationale for monitoring the blood concentration of a therapeutic drug?
A.
To monitor significant drug-drug interactions
B.
To determine drug concentrations in a pathophysiological state
C.
To monitor drugs with a broad therapeutic range
D.
To check patient compliance
Question #5
For a therapeutic drug that has a short half-life, for example levetiracetam, when is the appropriate time to collect a blood sample for therapeutic drug assessment?
A.
Immediately after a dose of the drug is given.
B.
There is no specific time that is the best for blood collection.
C.
Immediately before a dose of the drug is given.
D.
At 8 AM, when liver metabolism is highest.
Question #6
A positive urine immunoassay screening test for a drug of abuse must be confirmed by
A.
GC-MS.
B.
a more sensitive and specific immunoassay procedure.
C.
a spot test.
D.
electrophoresis.
Question #7
The correct formula for determining anion gap is
A.
[Na+] + [Cl− + [HCO3-]
B.
[HCO3-] − [Na+ + Cl−].
C.
[Na+] − [Cl− + [HCO3-]
D.
[Cl−] + [Na+ + [HCO3-]
Question #8
Which one of the following best explains the toxic effect of acetaminophen overdose?
A.
The myocardial infarction is caused by the effect on respiratory centers in the brain and eventual lack of stimulation of the heart.
B.
The hepatic necrosis is caused by depletion of a substance in the liver and eventual accumulation of the oxidized metabolite.
C.
The metabolic acidosis produced is caused by increased formation of formic acid by the liver during metabolism.
D.
The coma produced is caused by an immediate decrease in sensitivity to CO2 concentration through depression of respiratory centers in the brain.
Question #9
The most common laboratory method for detection, discrimination, and quantitation of alcohols in biologic specimens is
A.
immunoassay.
B.
HPLC.
C.
spectrophotometry.
D.
flame ionization gas chromatography (GC).
Question #10
To recognize a poisoning pattern, groups of drugs with similar actions, symptoms, and clinical signs are examined. These common signs and symptoms are referred to as the
A.
pattern constellation.
B.
toxin effect.
C.
toxidrome.
D.
metabolic pattern.
Question #11
If 30% of the nucleotides in a genome are A (adenine), what would be the percentage of nucleotides that are G (guanine)?
A.
60%
B.
30%
C.
20%
D.
40%
Question #12
The proteins that wrap DNA tightly to condense it into nucleosomes are called
A.
lysosomes.
B.
nucleotides.
C.
hormones.
D.
histones.
Question #13
DNA and RNA differ, in part, because of their sugar molecules. What is missing on the DNA sugar that is present on the RNA sugar?
A.
Methyl group
B.
Hydrogen
C.
Hydroxyl group
D.
Phosphate group
Question #14
In regard to the components of the genetic code, a “codon” is a
A.
phosphate group, a ribose sugar, and nitrogen.
B.
polymeric molecule composed of nucleic acids.
C.
sequence of three nucleotides.
D.
sequence of nucleotides that codes for a protein.
Question #15
What is the key enzyme used in a polymerase chain reaction (PCR)?
A.
Restriction enzyme
B.
Lysozyme
C.
Polymerase
D.
Transcriptase
Question #16
When performing a PCR procedure, what is the best control to rule out contamination for the presence of amplicon?
A.
dTTP control
B.
Positive control
C.
Oligoligated control
D.
Blank control
Question #17
In the dideoxy-termination sequencing method, what causes the termination of the newly synthesized DNA strand?
A.
Addition of a dideoxynucleotide
B.
Deletion of a deoxyribonucleotide
C.
Addition of a ribonucleotide
D.
Addition of a deoxyribonucleotide
Question #18
The annealing step in a PCR involves
A.
adding nucleotides to primed sites of the DNA strands.
B.
making a cDNA from an mRNA strand.
C.
unwinding and separating the double-stranded DNA.
D.
binding of the primers to the single-stranded DNA.
Question #19
Which one of the following is a similarity between bacterial and human genomes?
A.
Structure of chromosomes
B.
Number of genes
C.
Presence of double-stranded DNA
D.
Number of chromosomes
Question #20
If you were interested in studying plasmid structure, which one of the following cell types would be appropriate for you to examine?
A.
All cell types
B.
Bacterial cells
C.
Human cells
D.
Fungal cells
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