Chem 40005 - Clinical Chemistry » Summer 2021 » Module 9 Quiz
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Question #1
The period of time during which the concentration of a therapeutic drug decays by 50% is referred to as the drug’s
A.
volume of distribution.
B.
dosing curve.
C.
half-life.
D.
subtherapeutic range.
Question #2
If a drug is acidic in nature, which of the following proteins will it associate with primarily for transport and distribution?
A.
α1-Glycoprotein
B.
Albumin, Lipoprotein, and α1-Glycoprotein
C.
Albumin
D.
Lipoprotein
Question #3
Which of the following could account for drug toxicity following a prescribed dose?
A.
Increased drug metabolism caused by central nervous system disease
B.
Using a different route of administration than is typically used for that drug
C.
Decreased renal elimination leading to increased free drug concentration
D.
Using a single drug as opposed to multiple drugs for treatment
Question #4
Which one of the following is not a good rationale for monitoring the blood concentration of a therapeutic drug?
A.
To determine drug concentrations in a pathophysiological state
B.
To monitor significant drug-drug interactions
C.
To monitor drugs with a broad therapeutic range
D.
To check patient compliance
Question #5
For a therapeutic drug that has a short half-life, for example levetiracetam, when is the appropriate time to collect a blood sample for therapeutic drug assessment?
A.
Immediately after a dose of the drug is given.
B.
Immediately before a dose of the drug is given.
C.
There is no specific time that is the best for blood collection.
D.
At 8 AM, when liver metabolism is highest.
Question #6
A positive urine immunoassay screening test for a drug of abuse must be confirmed by
A.
a spot test.
B.
electrophoresis.
C.
a more sensitive and specific immunoassay procedure.
D.
GC-MS.
Question #7
The correct formula for determining anion gap is
A.
[HCO3-] − [Na+ + Cl−].
B.
[Na+] + [Cl− + [HCO3-]
C.
[Cl−] + [Na+ + [HCO3-]
D.
[Na+] − [Cl− + [HCO3-]
Question #8
Which one of the following best explains the toxic effect of acetaminophen overdose?
A.
The metabolic acidosis produced is caused by increased formation of formic acid by the liver during metabolism.
B.
The hepatic necrosis is caused by depletion of a substance in the liver and eventual accumulation of the oxidized metabolite.
C.
The myocardial infarction is caused by the effect on respiratory centers in the brain and eventual lack of stimulation of the heart.
D.
The coma produced is caused by an immediate decrease in sensitivity to CO2 concentration through depression of respiratory centers in the brain.
Question #9
The most common laboratory method for detection, discrimination, and quantitation of alcohols in biologic specimens is
A.
flame ionization gas chromatography (GC).
B.
immunoassay.
C.
HPLC.
D.
spectrophotometry.
Question #10
To recognize a poisoning pattern, groups of drugs with similar actions, symptoms, and clinical signs are examined. These common signs and symptoms are referred to as the
A.
toxidrome.
B.
metabolic pattern.
C.
toxin effect.
D.
pattern constellation.
Question #11
If 30% of the nucleotides in a genome are A (adenine), what would be the percentage of nucleotides that are G (guanine)?
A.
30%
B.
60%
C.
20%
D.
40%
Question #12
The proteins that wrap DNA tightly to condense it into nucleosomes are called
A.
histones.
B.
hormones.
C.
lysosomes.
D.
nucleotides.
Question #13
DNA and RNA differ, in part, because of their sugar molecules. What is missing on the DNA sugar that is present on the RNA sugar?
A.
Hydrogen
B.
Methyl group
C.
Phosphate group
D.
Hydroxyl group
Question #14
In regard to the components of the genetic code, a “codon” is a
A.
sequence of nucleotides that codes for a protein.
B.
polymeric molecule composed of nucleic acids.
C.
sequence of three nucleotides.
D.
phosphate group, a ribose sugar, and nitrogen.
Question #15
What is the key enzyme used in a polymerase chain reaction (PCR)?
A.
Transcriptase
B.
Polymerase
C.
Lysozyme
D.
Restriction enzyme
Question #16
When performing a PCR procedure, what is the best control to rule out contamination for the presence of amplicon?
A.
Positive control
B.
dTTP control
C.
Blank control
D.
Oligoligated control
Question #17
In the dideoxy-termination sequencing method, what causes the termination of the newly synthesized DNA strand?
A.
Addition of a deoxyribonucleotide
B.
Addition of a ribonucleotide
C.
Deletion of a deoxyribonucleotide
D.
Addition of a dideoxynucleotide
Question #18
The annealing step in a PCR involves
A.
making a cDNA from an mRNA strand.
B.
adding nucleotides to primed sites of the DNA strands.
C.
unwinding and separating the double-stranded DNA.
D.
binding of the primers to the single-stranded DNA.
Question #19
Which one of the following is a similarity between bacterial and human genomes?
A.
Number of genes
B.
Number of chromosomes
C.
Presence of double-stranded DNA
D.
Structure of chromosomes
Question #20
If you were interested in studying plasmid structure, which one of the following cell types would be appropriate for you to examine?
A.
All cell types
B.
Fungal cells
C.
Bacterial cells
D.
Human cells
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