Chem 221 - Biochemistry for Science Majors » Fall 2021 » L4 Amino Acids and Proteins
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Question #1
The chirality of an amino acid results from the fact that its α carbon:
A.
is a carboxylic acid
B.
is in the L absolute configuration in naturally occurring proteins
C.
is bonded to four different chemical groups
D.
has no net charge
E.
is symmetric
Question #2
Amino acids are ampholytes because they can function as either a(n):
A.
acid or a base
B.
neutral molecule or an ion
C.
standard or a nonstandard monomer in proteins
D.
polar or a nonpolar molecule
E.
transparent or a light-absorbing compound
Question #3
Titration of valine by a strong base, for example NaOH, reveals two pK's. The titration reaction occurring at pK2 (pK2 = 9.62) is:
A.
—COO– + —NH2+ → —COOH + —NH2
B.
—NH2 + OH– → —NH– + H2O
C.
—NH3+ + OH– → —NH2 + H2O
D.
—COOH + OH– → —COO– + H2O
E.
—COOH + —NH2 → —COO– + —NH2+
Question #4
For amino acids with neutral R groups, at any pH below the pI of the amino acid, the population of amino acids in solution will have:
A.
positive and negative charges in equal concentration
B.
a net negative charge
C.
a net positive charge
D.
no net charge
E.
no charged groups
Question #5
The formation of a peptide bond between two amino acids is an example of a(n) ______________ reaction.
A.
isomerization
B.
oxidation reduction
C.
cleavage
D.
condensation
E.
group transfer
Question #6
At the isoelectric pH of a tetrapeptide:
A.
two internal amino acids of the tetrapeptide cannot have ionizable R groups
B.
there are four ionic charges
C.
the amino and carboxyl termini are not charged
D.
the total net charge is zero
E.
only the amino and carboxyl termini contribute charge
Question #7
A prosthetic group is:
A.
synonymous with “protomer”
B.
a fibrous region of a globular protein
C.
a part of the protein that is not composed of amino acids
D.
a subunit of an oligomeric protein
E.
a nonidentical subunit of a protein with many identical subunits
Question #8
Which one of the following amino acids contains an aromatic group?
A.
Arginine
B.
Methionine
C.
Glycine
D.
Leucine
E.
Phenylalanine
Question #9
An essential amino acid is one that
A.
is essentially easy to synthesize
B.
is essential to flagella motion
C.
the body can synthesize under essential conditions
D.
the body cannot synthesize
Question #10
Which of the following pairs of amino acids would carry a negative charge on their side chain at pH 8.0?
A.
Asparagine & Glutamine
B.
Histidine & Lysine
C.
Aspartate & Glutamate
D.
Leucine & Glycine
Question #11
How many different standard amino acids are there?
A.
3
B.
20
C.
an infinite number
D.
100
Question #12
Of the 20 standard amino acids, only ___________ is not optically active (nonchiral). The reason is that its side chain ___________.
A.
glycine; is unbranched
B.
alanine; is a simple methyl group
C.
lysine; contains only nitrogen
D.
glycine; is a hydrogen atom
E.
proline; forms a covalent bond with the amino group
Question #13
Which of the following is an amino acid?
A.
Glycine
B.
Alanine
C.
Serine
D.
Proline
Question #14
A protease
A.
increases the rate of proteolysis
B.
All the above statements are correct
C.
is an enzyme that catalyzes proteolysis, the breakdown of proteins into smaller polypeptides or single amino acids
D.
is also called a peptidase or proteinase
E.
cleaves proteins by the addition of a molecule of water to a peptide bond
Question #15
Proteases
A.
Degrade proteins
B.
Cleave peptide bonds
C.
cleaves disulfide bonds
D.
Produce amino acids or short peptides
E.
three of the choices are correct
Question #16
Chose the best true statement
A.
Cleave all peptide bonds
B.
Proteases are involved in many biological functions, including digestion of eaten proteins, and protein catabolism
C.
Proteases can cleave at specific points in the peptide chain
D.
Proteases are involved in anabolism
E.
Two of the statement are incorrect
Question #17
The fully protonated form of histidine has a ____________charge.
A.
+1
B.
+4
C.
+2
D.
+3
Question #18
Which of the following amino acids has a net negative charge at physiologic pH (~7.4)?
A.
Histidine
B.
Lysine
C.
Glutamic Acid
D.
Asparagine
Question #19
Based on the pKa values given in the attached table (see canvas tables), in there any amino acid among the ones in the list below that could serve as a buffer at pH 8.0?
A.
Cysteine
B.
Tyrosine
C.
Leucine
D.
Glutamic acid
E.
Histidine
Question #20
At pH = 0, the net charge on glutamic acid is:____________
A.
+2
B.
-1
C.
+1
D.
0
Question #21
At pH = 13, the net charge on lysine is:____________
A.
+2
B.
+3
C.
+1
D.
-1
Question #22
What is the charge of the dipeptide Ala-Lys a pH = 12?
A.
+2
B.
-1
C.
+1
D.
0
Question #23
The lowest charge possible for glutamic acid is
A.
-2
B.
-1
Question #24
The charge of cysteine at pH below 2 is
A.
-2
B.
-1
C.
0
D.
+1
Question #25
The charge of glutamic acid at pH > 10 is
A.
-2
B.
+2
C.
0
D.
+1
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