Biol 303 - Intermediate Cell Biology » Fall 2021 » Pre-Quiz for Journal Article 2

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Question #1
The paper has proven which of the following ideas/hypotheses:
A.   DGJ can promote the trafficking of wild-type α-Gal A to lysosomes. DGJ can promote the trafficking of mutant α-Gal A to lysosomes. Mannose 6-phosphate can increase the amount of mutant α-Gal A trafficked to lysosomes.
B.   DGJ can promote the trafficking of mutant α-Gal A to lysosomes. Mutant α-Gal A enzyme can clear Gb3 accumulation in lysosomes of human Fabry fibroblasts. DGJ treatment increases mutant α-Gal A activity.
C.   DGJ can promote the trafficking of wild-type α-Gal A to lysosomes. Mannose 6-phosphate can increase the amount of mutant α-Gal A trafficked to lysosomes. DGJ treatment increases mutant α-Gal A activity.
D.   DGJ can promote the trafficking of wild-type α-Gal A to lysosomes. Mannose 6-phosphate can increase the amount of mutant α-Gal A trafficked to lysosomes. Mutant α-Gal A enzyme can clear Gb3 accumulation in lysosomes of human Fabry fibroblasts.
Question #2
Gb3 accumulates in lysosomes because it is not degraded by the mutant α-Gal A found in the lysosome.
A.   TRUE
B.   FALSE
Question #3
The difference between the cell lines TgN and TgM is that one is a fibroblast cell and the other a transgenic fibroblast cell.
A.   FALSE
B.   TRUE
Question #4
What is the role of BiP?
A.   It tags the mutant α-Gal A for the proteasome.
B.   It acts to traffic α-Gal A to the lysosome
C.   It assists in the folding of α-Gal A
D.   It accumulates in the lysosome
Question #5
The optimal dose of DGJ used to increase localization of α-Gal A to lysosomes was
A.   160uM
B.   120 uM
C.   80 uM
D.   20 uM

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