Chem 221 - Biochemistry for Science Majors » Fall 2021 » L14 Membranes
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Question #1
Peripheral membrane proteins:
A.
may have functional units on both sides of the membrane
B.
can be released from membranes only by treatment with detergents
C.
penetrate deeply into the lipid bilayer
D.
are generally noncovalently bound to membrane lipids
Question #2
An integral membrane protein can be extracted with:
A.
hot water
B.
a chelating agent that removes divalent cations
C.
a solution of high ionic strength
D.
a buffer
E.
a solution containing detergent
Question #3
Which of these statements is generally true of integral membrane proteins?
A.
They can be removed from the membrane with high salt or mild denaturing agents.
B.
The secondary structure in the transmembrane region consists solely of alpha-helices or beta-sheets.
C.
The domains that protrude on the cytoplasmic face of the plasma membrane nearly always have covalently attached oligosaccharides.
D.
They undergo constant rotational motion that moves a given domain from the outer face of a membrane to the inner face and then back to the outer.
Question #4
Which of these is a general feature of the lipid bilayer in all biological membranes?
A.
Individual lipid molecules are free to diffuse laterally in the surface of the bilayer.
B.
Individual lipid molecules in one face (monolayer) of the bilayer readily diffuse (flip-flop) to the other monolayer.
C.
The bilayer is stabilized by covalent bonds between neighboring phospholipid molecules.
D.
Polar, but uncharged, compounds readily diffuse across the bilayer.
E.
The polar head groups face inward toward the inside of the bilayer.
Question #5
The fluidity of the lipid chains in the interior of a bilayer is generally INCREASED by:
A.
an increase in fatty acyl chain length.
B.
the binding of water to the fatty acyl side chains.
C.
a decrease in temperature.
D.
an increase in the number of double bonds in fatty acids.
Question #6
When a bacterium such as E. coli is shifted from a warmer growth temperature to a cooler growth temperature, it compensates by:
A.
putting longer-chain fatty acids into its membranes.
B.
synthesizing thicker membranes to insulate the cell.
C.
increasing its metabolic rate to generate more heat.
D.
putting more unsaturated fatty acids into its membranes.
E.
shifting from aerobic to anaerobic metabolism.
Question #7
Facilitated diffusion through a biological membrane is:
A.
driven by a difference of solute concentration
B.
endergonic
C.
driven by ATP
D.
generally irreversible
E.
not specific with respect to the substrate
Question #8
The type of membrane transport that uses ion gradients as the energy source is:
A.
simple diffusion
B.
secondary active transport
C.
facilitated diffusion
D.
primary active transport
E.
passive transport
Question #9
Choose the FALSE statement.
A.
There are electrostatic and hydrogen-bonding attractions between the polar head groups and water molecules.
B.
The outside surface of a beta barrel is hydrophylic
C.
An entropy increase powers diffusion across the membrane.
D.
In accord with the Second Law of Thermodynamics, molecules spontaneously move from a region of higher concentration to one of lower concentration
Question #10
Which one of the following processes could result in the net movement of a substance into a cell, if the substance is more concentrated in the cell than in the surroundings?
A.
diffusion
B.
None of the choices are correct
C.
osmosis
D.
active transport
E.
facilitated diffusion
Question #11
Which of the following terms is used to describe a membrane protein capable of moving substances from a low to a high concentration?
A.
oxidizer
B.
transporter
C.
diffuser
D.
pump
E.
reducer
Question #12
Diffusion is the movement of molecules from
A.
An area of equilibrium to an area of high concentration
B.
An area of low concentration to an area of high concentration
C.
An area of high concentration to an area of low concentration
D.
All of the above
Question #13
Active transport and passive transport differ in that active transport requires
A.
Energy
B.
Concentrated solutes
C.
Water
D.
Carrier proteins
Question #14
Choose the false statement
A.
The transport of a molecule up its gradient is an exergonic process
B.
Movement of one molecule down its gradient is an entropically driven process
C.
The transport of a molecule up its gradient is an energy-requiring process.
D.
Passage through a channel allows polar and charged compounds to avoid the hydrophobic core of the plasma membrane, which would otherwise block their entry into the cell.
Question #15
What important property is conferred on membranes by transport systems?
A.
amphipathic nature
B.
None of the answers is correct.
C.
bilayer
D.
selective permeability
E.
asymmetry
Question #16
What is the most common process by which lipids and proteins move in the membrane bilayer?
A.
translocation
B.
kinesin-mediated movement
C.
lateral diffusion
D.
asymmetric longitudinal flipping
E.
flip-flopping
Question #17
What membrane components contain carbohydrates?
A.
glycolipids
B.
cholesterol
C.
integral membrane proteins in contact with the cytoplasm
D.
lipid-linked proteins
Question #18
Membranes are PRIMARILY comprised of
A.
lipids and proteins
B.
None of the answers is correct.
C.
carbohydrates
D.
All of the answers are correct
Question #19
How many molecules-thick are membranes?
A.
one
B.
None of the answers is correct.
C.
varying thickness, depending on structure
D.
two
E.
infinite
Question #20
Which of the following membranes would be the most fluid?
A.
a bilayer made of lipids with polyunsaturated 18 carbon-fatty acids
B.
a bilayer made of lipids with saturated 18 carbon-fatty acids
C.
a bilayer made of lipids with polyunsaturated 16 carbon-fatty acids
D.
a bilayer made of lipids with saturated 16 carbon-fatty acids
E.
All of the above are equivalent in fluidity.
Question #21
Carbohydrate residues attached to the membrane lipids are almost always
A.
positioned on the inside center of the bilayer.
B.
positioned equally on both sides of the membrane.
C.
also covalently attached to membrane proteins
D.
positioned on the extracellular side of the membrane.
E.
positioned on the intracellular side of the membrane.
Question #22
The degree of membrane fluidity in bacteria depends mainly on the percentage of
A.
free fatty acids.
B.
glycolipids
C.
unsaturated fatty acids.
D.
lipids that contain sphingosine.
Question #23
A substance can only be accumulated against its electrochemical gradient by:
A.
Passage through ion channels
B.
Active transport
C.
facilitated diffusion
D.
Diffusion through a uniport
Question #24
The low incidence of protein or lipid flip-flop in a membrane preserves
A.
membrane fluidity and membrane melting temperatures.
B.
All of the answers are correct.
C.
membrane asymmetry
D.
membrane melting temperatures.
E.
membrane fluidity
Question #25
Which of the following helps regulate membrane fluidity in animals?
A.
magnesium ions
B.
proteins
C.
ATP
D.
cholesterol
E.
None of the answers is correct.
Question #26
Which of the following statements about the lipid constituents of membranes is correct?
A.
Lateral movement of membrane lipids occurs rapidly within the plane of the bilayer.
B.
Transverse movement of membrane lipids within the bilayer is unrestricted.
C.
The inner and outer halves of the lipid bilayer are identical.
D.
Lateral movement of membrane lipids is catalysed by special proteins.
Question #27
Which of the following statements about membrane fluidity is correct?
A.
Membrane fluidity is increased when there is a high proportion of cis unsaturated fatty acids in the glycerophosphate molecules that make up the bilayer.
B.
Membrane fluidity is increased when there is a high proportion of trans unsaturated fatty acids in the glycerophosphate molecules that make up the bilayer.
C.
Membrane fluidity is decreased when there is a high proportion of cis unsaturated fatty acids in the glycerophosphate molecules that make up the bilayer.
D.
Membrane fluidity is increased when there is a high proportion of saturated fatty acids in the glycerophosphate molecules that make up the bilayer.
Question #28
Which of the following statements about membrane proteins is not correct?
A.
Integral membrane proteins are anchored to the lipid bilayer by ionic bonds.
B.
Integral membrane proteins have ends rich in hydrophilic amino acids.
C.
Integral membrane proteins have transmembrane domains rich in hydrophobic amino acids.
D.
Transmembrane porins have hydrophilic amino acids that point inwards in the beta-barrels.
Question #29
Which of the following statements about the functions of cell membranes is not correct?
A.
Cell membranes retain the contents of cells.
B.
Cell membranes are permeable to most inorganic ions.
C.
Cell membranes maintain the shape of cells.
D.
Cell membranes are impermeable to most molecules.
Question #30
Which of the following statements about the transport of substances through a cell membrane is correct?
A.
Small polar molecules require specific transport systems for passage across a membrane.
B.
Small polar molecules cannot be transported through a cell membrane against a concentration gradient.
C.
Small polar molecules can diffuse through a cell membrane along a concentration gradient.
D.
Small inorganic ions can diffuse through a cell membrane along a concentration gradient.
Question #31
Fluidity of phospholipid bilayer is increased by
A.
cholesterol at certain temperatures
B.
steroid lipids at certain temperatures
C.
double bonds between carbon atoms in the fatty acid tails
D.
poor alignment of the fatty acids tails
E.
all of the above
Question #32
Gases such as oxygen and carbon dioxide cross the plasma membrane by:
A.
primary active transport
B.
secondary active transport
C.
passive diffusion through the lipid bilayer
D.
specific gas transport proteins
Question #33
A student is trying to determine the type of membrane transport occurring in a cell. She finds that the molecule to be transported is very large and polar, and when transported across the membrane, no energy is required. Which of the following is the most likely mechanism of transport?
A.
Simple diffusion
B.
Facilitated diffusion
C.
Symport
D.
Pump
Question #34
During diffusion, when the concentration of molecules on both sides of a membrane is the same, the molecules will
A.
move across the membrane to the outside of the cell.
B.
move across the membrane to the inside of the cell.
C.
continue to move across the membrane in both directions.
D.
stop moving across the membrane.
Question #35
The diffusion of water across a selectively permeable membrane is called
A.
osmosis.
B.
pinocytosis.
C.
osmotic pressure.
D.
active transport.
Question #36
A cell in a hypotonic solution will
A.
swell
B.
shrink
C.
impossible to tell
D.
stay the same size
Question #37
A.
Solution
B.
Isotonic
C.
Diffusion
D.
Osmosis
Question #38
Concentration of solute molecules outside the cell is equal to that inside the cell
A.
Homeostasis
B.
Isotonic
C.
Hypertonic
D.
Hypotonic
Question #39
A difference in concentrations across space
A.
Osmosis
B.
Concentration gradient
C.
Diffusion
D.
Semi-permeable
Question #40
When salt is poured on a slug, it dies because
A.
water moves out of the slug, causing dehydration
B.
salt moves out of the slug, depriving it of essential minerals
C.
water moves into the slug, causing it to swell
D.
salt moves into the slug, poisoning it
Question #41
Which of the following membranes would be the most fluid?
A.
a bilayer made of lipids with polyunsaturated 16 carbon-fatty acids
B.
a bilayer made of lipids with polyunsaturated 18 carbon-fatty acids
C.
a bilayer made of lipids with saturated 18 carbon-fatty acids
D.
a bilayer made of lipids with saturated 16 carbon-fatty acids
E.
All of the above are equivalent in fluidity.
Question #42
What forms the channels and pumps in the phospholipid bilayer?
A.
hydrophilic heads
B.
Carbohydrates
C.
lipids
D.
Proteins
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