HSCI 488 - Epidemiology: Introduction to the Study of Diseases » 2019 » Final Exam
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Question #1
John Snow’s conclusions that contaminated water was associated with cholera was based entirely on... (choose one best answer)
A.
the support of Registrar General William Farr for his hypothesis.
B.
his understanding of Jenner’s work with a cholera vaccine.
C.
observational data.
D.
knowledge of the pathogenic organism, Vibrio cholerae.
Question #2
Edward Jenner was able to find a vaccination against smallpox because (choose one best answer):
A.
he randomly allocated dairy maids to "exposed" and "unexposed" smallpox groups.
B.
his work with cowpox and cholera resulted in his being labeled the "father of variolation."
C.
he observed that dairy maids who developed cowpox did not develop smallpox during outbreaks.
D.
he understood the ethics of vaccination trials and the importance of informed consent.
Question #3
In present time the three most common causes of death in the U.S. are … (choose one best answer)
A.
pneumonia, tuberculosis, and diarrhea and enteritis.
B.
diabetes, stroke, and suicide
C.
heart diseases, malignant neoplasms, chronic lower respiratory diseases
D.
unintentional injuries, liver disease, and cancer.
Question #4
Cervical cancer screening (PAP smear) is an example of secondary prevention: (choose one best answer)
A.
TRUE
B.
FALSE
Question #5
Tertiary prevention denotes the early detection of a disease to reduce its severity and complications. (choose one best answer)
A.
TRUE
B.
FALSE
Question #6
Dengue fever is a disease caused by a virus that spreads to people mostly from the bites of a special type of mosquito, Aedes aegypti (yellow fever mosquito). Such transmission is an example of (choose one best answer):
A.
direct transmission by common vehicle
B.
indirect transmission by vector
C.
indirect transmission by common vehicle
D.
direct transmission by person-to-person contact
Question #7
A disease that is habitually present in a population/community is defined as … (choose one best answer):
A.
Epidemic disease
B.
Panzootic disease
C.
Endemic disease
D.
Epizootic disease
E.
Pandemic disease
Question #8
Case-fatality (stated as a percent) is... (choose the one best answer)
A.
a measure of the mortality rate of a disease
B.
a measure of the severity of a disease
C.
a measure of the incidence rate of a disease
D.
a measure of the risk of a disease
E.
a measure of the duration of a disease
Question #9
In a screening test for a cancer, out of 150 people tested, 20 tested positive but actually did not have disease. These 20 people could be referred to as … (choose one best answer):
A.
False negatives
B.
True positives
C.
True negatives
D.
False positives
Question #10
Using a test of given sensitivity and specificity, the positive predictive value of the test typically increases as disease prevalence decreases. (choose one best answer)
A.
TRUE
B.
FALSE
Question #11
Sequential testing results in an increased of net specificity and loss in net sensitivity. (choose one best answer)
A.
FALSE
B.
TRUE
Question #12
Power of the study is ... (choose one best answer).
A.
equal to 1 - β
B.
None of the present choices
C.
called a p-value
D.
called a Type II error
E.
called a Type I error
Question #13
A clinical trial was done of obesity reduction by liposuction versus prescription-only diet pills (i.e., medical). Following randomization, 23% of the liposuction group changed their mind and asked their doctors for diet pills and 28% of the diet pill group changed their mind and asked for liposuction This is an example of: (choose the one best answer)
A.
stratified randomization
B.
factorial noncompliance
C.
unmasking (i.e., unblinding)
D.
unplanned crossover
Question #14
The use of a placebo in a randomized clinical trial is a form of... (choose one best answer)
A.
planned crossover
B.
unplanned crossover
C.
factorial noncompliance
D.
masking exposure assignment
Question #15
In a cohort study incidence in exposed and unexposed groups can be calculated and compared. (choose one best answer)
A.
FALSE
B.
TRUE
Question #16
Which of the following is not an advantage of a prospective cohort study?
A.
Precise measurement of exposure is possible
B.
Recall bias is minimized compared with a case-control study
C.
Many exposures can be studied simultaneously
D.
Incidence rates can be calculated
E.
Many disease outcomes can be studied simultaneously
Question #17
The National Death Registry identifies deaths anywhere in the United States if linking information is known, such as sex, race, date of birth, and social security number. All of these variables were collected by UCLA from students in the class of 1953 at the time they were enrolled. Fifty years later, their UCLA grades were used to compare mortality rates among the upper fourth versus the lower fourth of the graduating class. This study is an example of a... (choose one best answer)
A.
cross-sectional study.
B.
prospective (or concurrent) cohort study.
C.
retrospective (or historical or non-concurrent) cohort study.
D.
case-control study.
Question #18
Odds ratio is a good estimate of relative risk (or risk ratio) under rare disease assumption. (choose one best answer)
A.
FALSE
B.
TRUE
Question #19
The most important step in case-control studies is … (choose one best answer)
A.
selection of unexposed
B.
selection of exposed
C.
selection of cases
D.
selection of controls
Question #20
One of disadvantages of using hospital-based controls is ... (choose one best answer):
A.
difficult to find
B.
hard to recruit
C.
less cooperative
D.
often are not representative of a general population in terms of exposure status
Question #21
Four thousand persons were interviewed by telephone in California between January and June, 2008. In this single-contact study, persons were asked about their height, weight and systolic blood pressure. The researchers combined the height and weight to form the body mass index (i.e., BMI) and found that the BMI was positively associated with systolic hypertension. This study is an example of a... (choose one best answer)
A.
prospective cohort study.
B.
retrospective cohort study .
C.
cross-sectional study.
D.
case-control study.
Question #22
The most important criteria to assess causation is ... (choose one best answer):
A.
the temporal relationship between exposure factor and disease
B.
the strength of the association between exposure factor and disease
C.
the dose-response relationship between exposure factor and disease
D.
the biological plausibility of the association between exposure factor and disease
Question #23
In observational studies one of the main biases that may affect the results of a study is confounding.
A.
TRUE
B.
FALSE
Question #24
In a study on the association between consuming greasy food and acne, people without acne may be more likely to forget/misremember their exposure to greasy foods than those with acne. The potential distortion in results this may lead to can be identified as a form of recall bias. (choose one best answer)
A.
TRUE
B.
FALSE
Question #25
Confounding is one of the most important problems to consider and to account for when interpreting an observed association between an exposure and a disease. (choose one best answer)
A.
FALSE
B.
TRUE
Question #26
Undue influence in a research study occurs when an offer of an excessive or inappropriate reward or other gesture is offered to obtain consent and compliance. (choose one best answer)
A.
TRUE
B.
FALSE
Question #27
The primary purpose of an Institutional Review Board (IRB) is to ensure that a research study generates the highest amount of profit possible. (choose one best answer)
A.
TRUE
B.
FALSE
Question #28
Criterion for causation, stating that if a relationship is causal an exposure of interest should precede a disease of interest is called temporality. (choose one best answer):
A.
TRUE
B.
FALSE
Question #29
Criterion for causation, stating that if a relationship is causal, we would be more likely to expect to find it repeatedly in different studies and in different populations is called specificity.
A.
TRUE
B.
FALSE
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