Phar 642 - Principles of Drug Action » Spring 2022 » Neuropharmacology
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Question #1
What part of the nervous system involves signals being sent from the body to the brain?
A.
Sympathetic nervous system
B.
Efferent division
C.
Parasympathetic nervous system
D.
Afferent division
Question #2
A patient involved in a motor vehicle accident damaged his spinal cord in the cervical region. What part of the patient's body is most likely paralyzed?
A.
From the upper torso, down
B.
Just the backs of the legs
C.
From the neck, down
D.
From the hips, down
Question #3
What neurotransmitter diffuses through cell membranes to bind to intracellular receptors?
A.
Glutamate
B.
GABA
C.
Nitric Oxide
D.
Acetylcholine
Question #4
What cranial nerve that innervates the eye contains parasympathetic fibers?
A.
Optic
B.
Abducent
C.
Trochlear
D.
Oculomotor
Question #5
What components of the peripheral nervous system involves the release of acetylcholine from the pre-synaptic neuron into the synapse and activation of nicotinic acetylcholine receptors?
A.
Post-ganglionic sympathetic neurons synapsing with smooth muscle. Post-ganglionic parasympathetic neurons synapsing with smooth muscle
B.
Post-ganglionic sympathetic neurons synapsing with smooth muscle. Autonomic neurons synapsing with the adrenal gland. Post-ganglionic parasympathetic neurons synapsing with smooth muscle
C.
Autonomic neurons synapsing with the adrenal gland. Somatic neurons synapsing with skeletal muscle. Pre-ganglionic parasympathetic neurons synapsing with post-ganglionic neurons. Pre-ganglionic sympathetic neurons synapsing with post-ganglionic neurons
D.
Somatic neurons synapsing with skeletal muscle. Post-ganglionic sympathetic neurons synapsing with smooth muscle. Post-ganglionic parasympathetic neurons synapsing with smooth muscle
Question #6
Match each cholinergic and adrenergic receptor to their receptor type. nicotinic acetylcholine receptor
A.
Gi coupled receptor
B.
Ligand-gated ion channel
C.
Gq coupled receptor
Question #7
Match each cholinergic and adrenergic receptor to their receptor type. M1 muscarinic acetylcholine receptor
A.
Gq coupled receptor
B.
Ligand-gated ion channel
C.
Gs coupled receptor
Question #8
Match each cholinergic and adrenergic receptor to their receptor type. alpha-1 adrenergic receptor
A.
Gi coupled receptor
B.
Gq coupled receptor
C.
Gs coupled receptor
Question #9
Match each cholinergic and adrenergic receptor to their receptor type. alpha-2 adrenergic receptor
A.
Ligand-gated ion channel
B.
Gq coupled receptor
C.
Gi coupled receptor
Question #10
Match each cholinergic and adrenergic receptor to their receptor type. beta-adrenergic receptors
A.
Gq coupled receptor
B.
Gs coupled receptor
C.
Gi coupled receptor
Question #11
When ion channels open in a neuron cell membrane, what will happen to resistance and current?
A.
Resistance will increase and current will increase
B.
Resistance will decrease and current will decrease
C.
Resistance will increase and current will decrease
D.
Resistance will decrease and current will increase
Question #12
What is the primary reason why potassium does not leave a neuron at rest, even though potassium leak channels allow potassium to diffuse freely?
A.
The electrical driving force keeps potassium from leaving the cell
B.
Potassium leak channels must first be activated before potassium can enter or exit
C.
The chemical driving force makes potassium enter the cell instead of leaving
D.
There is no chemical gradient for potassium, so no driving force
Question #13
What would be the most likely outcome of depolarizing a neuron if voltage gated sodium channels only has the S4 gate (and not the ball and chain gate)?
A.
Sodium channels would not open
B.
The cell would get stuck in the repolarized state
C.
Sodium channel activation would cause sodium efflux instead of influx
D.
The S4 gate would be unable to close
Question #14
A 32-year-old female patient was recently diagnosed with epilepsy and started on a drug that increases the activity of GABA-A receptors to help prevent seizures. What does this drug most likely do to action potentials in the patient's brain?
A.
It makes it more difficult for action potentials to fire
B.
It helps neurons repolarize more rapidly
C.
It extends the absolute refractory period
D.
It makes action potentials shorter
Question #15
What type of ion channel is activated in neuron terminals to initiate the process of neurotransmitter release?
A.
Voltage gated potassium channels
B.
Voltage gated sodium channels
C.
Voltage gated chloride channels
D.
Voltage gated calcium channels
Question #16
What neurological disorder involves altered neural signaling due to demyelination of central nervous system neurons?
A.
Seizures
B.
Multiple Sclerosis
C.
Guillain Barre Syndrome
D.
Epilepsy
Question #17
What is the mechanism of action of suxamethonium?
A.
It directly activates voltage-gated sodium channels
B.
It directly activates nicotinic acetylcholine receptors
C.
It directly blocks nicotinic acetylcholine receptors
D.
It directly blocks voltage-gated sodium channels
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