Phar 642 - Principles of Drug Action » Spring 2022 » Pharmacokinetics and Drug Toxicity

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Question #1
What does the "M" represent in the pharmacokinetics acronym ADME?
A.   Multiple
B.   Metabolism
C.   Muscle
D.   Modification
Question #2
What drug delivery modality would result in the highest fractional bioavailability (F)?
A.   Intravenous
B.   Transdermal
C.   Rectal
D.   Oral
Question #3
What is an enteral route of drug administration that may avoid some of the effects of first-pass metabolism?
A.   Intrathecal
B.   Nasal
C.   Buccal
D.   Oral
Question #4
What is the most likely consequence of a drug being highly bound to serum albumin?
A.   It will readily cross the blood brain barrier
B.   It will penetrate barriers more readily in a basic environment
C.   It will be more likely to be eliminated renally
D.   It will compete with acidic and neutral drugs for albumin binding sites
Question #5
A female patient was recently diagnosed with epilepsy. What antiepileptic drug is least likely to reduce the effectiveness of the patient's oral contraceptives?
A.   Phenytoin
B.   Carbamazepine
C.   Phenobarbital
D.   Sodium valproate
Question #6
What is an example of a phase I metabolic reaction?
A.   Oxidation
B.   Acetylation
C.   Methylation
D.   Glucuronidation
Question #7
A patient was given 200mg of an IV drug. 100mg was eliminated after 2 hours. Assuming first-order elimination kinetics, how much of the drug will have been eliminated 6 hours after the initial administration?
A.   200mg
B.   25mg
C.   175mg
D.   100mg
Question #8
What pharmacokinetic process is most likely to involve the production of free radicals as a mechanism of toxicity?
A.   Metabolism
B.   Absorption
C.   Excretion
D.   Distribution
Question #9
What event is more likely to lead to apoptosis than necrosis?
A.   DNA damage
B.   Pancreatitis
C.   Infection
D.   Infarction
Question #10
What step of neoplasm formation involves the formation of new blood vessels?
A.   Metastasis
B.   Angiogenesis
C.   Proliferation
D.   Teratogenesis
Question #11
What strategy involves continual assessment of a drug's concentration?
A.   Therapeutic drug monitoring
B.   Patient centered care
C.     
D.   Medication therapy management

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