Phar 642 - Principles of Drug Action » Spring 2022 » Inflammation and Pain

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Question #1
What is a function of tumor necrosis factor a (TNFa)?
A.   Inhibition of angiogenesis
B.   Expression of adhesion molecules
C.   Fever initiation
D.   Anti-inflammatory actions
Question #2
What part of the arachidonic acid pathway increases the production of gastric mucus?
A.   Leukotrienes
B.   Thromboxane A2
C.   Lipoxygenase
D.   Prostaglandin E2
Question #3
A patient taking antihistamines felt drowsy shortly after each dose. What mechanism is most likely involved in this adverse effect?
A.   Increased activity of diacylglycerol
B.   Decreased activity of inositol triphosphate
C.   Increased activity of phospholipase C
D.   Decreased activity of adenylyl cyclase
Question #4
What molecular mechanism of action of corticosteroids most significantly contributes to their usefulness in the treatment of severe inflammation?
A.   Lipoxygenase inhibition
B.   Phospholipase A2 inhibition
C.   Cyclooxygenase inhibition
D.   Leukotriene inhibition
Question #5
A 10-year-old female stepped on a sharp object that penetrated the skin of her foot. She yelped in pain and hopped on the other foot. What type of pain did she experience that caused her to yelp?
A.   Breakthrough pain
B.   Neuropathic pain
C.   Somatic nociceptive pain
D.   Visceral nociceptive pain
Question #6
What type of pain would pelvic pain from menses be characterized as?
A.   Functional pain
B.   Neuropathic pain
C.   Visceral pain
D.   Breakthrough pain
Question #7
What effect does inflammation have on nociceptors?
A.   Nociceptors are activated and sensitized by inflammatory molecules
B.   Nociceptors are sensitized by inflammatory molecules
C.   Nociceptors are activated by inflammatory molecules
Question #8
What type of sodium channel found in pain neurons can be activate even with sustained depolarization?
A.   Nav1.7
B.   Nav1.9
C.   Nav1.8
D.   Nav1.3
Question #9
What is an example of hyperalgesia?
A.   Pain from being brushed by a feather
B.   Intense pain from mildly cold water
C.   Excruciating pain from a gentle slap on the back
D.   Severe pain with movement, despite no injury
Question #10
What opioid is a mixed agonist/antagonist of opioid receptors?
A.   Tramadol
B.   Codeine
C.   Methylnaltrexone
D.   Nalbuphine
Question #11
What is a demonstration of tolerance to a medication?
A.   When the drug is no longer taken, withdrawal symptoms occur
B.   Physical symptoms that occur when a medication is abruptly discontinued
C.   Compulsive drug seeking behavior
D.   A higher dose is required to achieve the same effect as when the patient was initially started the medication
Question #12
What analgesic has the highest risk of kidney injury AND gastrointestinal irritation as an adverse effect?
A.   Capsaicin
B.   Acetaminophen
C.   Celecoxib
D.   Morphine
E.   Naproxen
Question #13
What can be administered to patients in the case of acetaminophen overdose, if caught quickly?
A.   N-acetyl-p-benzoquinone imine
B.   N-acetylcysteine
C.   Glutathione
D.   Naloxone
Question #14
A 35-year-old female patient undergoing chemotherapy is considering cannabis as an option for pain control. How might cannabis be helpful for this patient’s pain?
A.   Chemicals in cannabis activate CB1 and CB2 receptors, reducing pain transmission and inflammation, respectively
B.   Chemicals in cannabis inhibit CB1 decreasing immune function
C.   Chemicals in cannabis activate CB1 receptors decreasing inflammation
D.   Chemicals in cannabis inhibit CB1 receptors, which decreases excitatory neurotransmission and thereby contributes to reduction of pain response
E.   Chemicals in cannabis activate CB2 receptors, which inhibits cancer cell growth that is contributing to the patient’s pain

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