Phar 642 - Principles of Drug Action » Spring 2022 » iRat 02

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Question #1
What drug delivery modality will most likely involve extensive first-pass metabolism?
A.   Buccal
B.   Oral
C.   Intramuscular
D.   Rectal
Question #2
A basic drug is highly plasma protein bound. What protein does it most likely bind to?
A.   Serum albumin
B.   α1-acid glycoprotein
C.   Cytochrome P450
D.   Glutathione
Question #3
What drug would be most likely to accumulate in adipose tissue?
A.   A large and ionically charged drug
B.   A large and uncharged drug
C.   A small and uncharged drug
D.   A small and ionically charged drug
Question #4
A patient recently started on warfarin therapy heard about the health benefits of St. John's Wort and decided to try it. What drug-drug interaction is most likely to occur?
A.   St. John's Wort will Induce the metabolism of warfarin, making it less effective
B.   St. John's wort and warfarin will compete for the Same metabolic enzyme, reducing their effectiveness
C.   St. John's Wort will inhibit the metabolism of warfarin, increasing the risk of overdose
D.   St. John's wort will displace warfarin from serum albumin, increasing the risk of overdose
Question #5
What type of chemical reaction is most likely to occur during phase Il metabolism?
A.   Conjugation
B.   Oxidation
C.   Reduction
D.   Hydrolysis
Question #6
What is an example of a pharmacodynamic drug-drug interaction?
A.   Two drugs compete for the same metabolic enzyme
B.   Two drugs have opposing effects on tissues
C.   One drug displaces another from its bound protein
D.   A drug induces the metabolism of another
Question #7
A patient presents with liquefactive necrosis. What was the most likely underlying cause?
A.   Pancreatitis
B.   Blood vessel inflammation
C.   Bacterial infection
D.   Limb ischemia
Question #8
What type of carcinogen increases the chance Of neoplasm formation primarily due to cell death and persistent regenerative growth?
A.   Immunosuppressants
B.   Teratogenic compounds
C.   Cytotoxic compounds
D.   Genotoxic compounds

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