Phar 642 - Principles of Drug Action » Spring 2022 » iRat 02

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Question #1
What drug delivery modality will most likely involve extensive first-pass metabolism?
A.   Buccal
B.   Rectal
C.   Intramuscular
D.   Oral
Question #2
A basic drug is highly plasma protein bound. What protein does it most likely bind to?
A.   Cytochrome P450
B.   α1-acid glycoprotein
C.   Glutathione
D.   Serum albumin
Question #3
What drug would be most likely to accumulate in adipose tissue?
A.   A small and uncharged drug
B.   A large and uncharged drug
C.   A small and ionically charged drug
D.   A large and ionically charged drug
Question #4
A patient recently started on warfarin therapy heard about the health benefits of St. John's Wort and decided to try it. What drug-drug interaction is most likely to occur?
A.   St. John's wort will displace warfarin from serum albumin, increasing the risk of overdose
B.   St. John's Wort will inhibit the metabolism of warfarin, increasing the risk of overdose
C.   St. John's Wort will Induce the metabolism of warfarin, making it less effective
D.   St. John's wort and warfarin will compete for the Same metabolic enzyme, reducing their effectiveness
Question #5
What type of chemical reaction is most likely to occur during phase Il metabolism?
A.   Conjugation
B.   Reduction
C.   Oxidation
D.   Hydrolysis
Question #6
What is an example of a pharmacodynamic drug-drug interaction?
A.   A drug induces the metabolism of another
B.   Two drugs have opposing effects on tissues
C.   Two drugs compete for the same metabolic enzyme
D.   One drug displaces another from its bound protein
Question #7
A patient presents with liquefactive necrosis. What was the most likely underlying cause?
A.   Bacterial infection
B.   Pancreatitis
C.   Blood vessel inflammation
D.   Limb ischemia
Question #8
What type of carcinogen increases the chance Of neoplasm formation primarily due to cell death and persistent regenerative growth?
A.   Immunosuppressants
B.   Cytotoxic compounds
C.   Teratogenic compounds
D.   Genotoxic compounds

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