Phar 642 - Principles of Drug Action » Spring 2022 » iRat 05
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Question #1
A 29-year-old female patient was prescribed mirtazapine, an atypical antidepressant, to treat depression. What molecular mechanism most likely contributes to the beneficial effects of this drug for this patient?
A.
increased release of GABA
B.
Activation of 5-HTI, 5-HT2 and 5-HT3 receptors
C.
Antagonism of ?-2 adrenergic receptors
D.
Decreased release of norepinephrine
Question #2
A 35-year-old male patient was prescribed an antidepressant drug that that is associated with an increased risk for serotonin syndrome. What is the most likely Sign of this adverse effect?
A.
Jaundice
B.
Sedation
C.
Bradycardia
D.
Hyperthermia
Question #3
A 19-year-old female patient was prescribed lithium for a newly diagnosed mood disorder. What disorder was this drug most likely prescribed to treat?
A.
Major depressive disorder
B.
persistent depressive disorder
C.
Premenstrual dysphoric disorder
D.
Bipolar disorder
Question #4
A 35-year-old male patient was prescribed an SSRI for a mood disorder. What neurochemical imbalance Will this drug primarily help treat?
A.
Decreased serotonin and elevated dopamine
B.
Decreased serotonin
C.
Decreased norepinephrine
D.
Decreased serotonin and norepinephrine
Question #5
A 35-year-old female patient with a history of migraine was recently diagnosed with depression and started on monotherapy an SSRI. What medication used to manage migraine pain should be avoided in this patient?
A.
Acetaminophen
B.
Celecoxib
C.
Aspirin
D.
Sumatriptan
Question #6
A 33-year-old male patient was brought to the emergency room with hypertensive crisis due to interaction between dietary tyramine and phenelzine. a monoamine oxidase inhibitor. What mechanism of tyramine most likely contributed to the patient's hypertension?
A.
Increased norepinephrine release
B.
Increased norepinephrine reuptake
C.
Decreased norepinephrine synthesis
D.
Decreased norepinephrine metabolism
Question #7
A 33-year-old female patient was recently Started on citalopram, an SSRI, for depression. HOW soon can the patient expect to see an improvement in her symptoms?
A.
In 1-6 weeks
B.
In 4-5 hours
C.
In 1-2 days
D.
In 3-6 months
E.
Immediately
Question #8
A 35-year-old male patient was prescribed venlafaxine, an SNRI, for a mood disorder. What neurochemical imbalance will this drug primarily help treat?
A.
Decreased norepinephrine
B.
Decreased serotonin and norepinephrine
C.
Decreased serotonin and elevated norepinephrine
D.
Decreased serotonin
Question #9
A 37-year-old female patient was prescribed a drug to treat panic disorder that acts as an antagonist of alpha-2 adrenergic receptors in the brain. What drug was the patient most likely prescribed?
A.
Propranolol
B.
Phenelzine
C.
Prazosin
D.
Mirtazapine
Question #10
An 8-year-old male patient was prescribed guanfacine for ADHD. What mechanism most likely Contributes to the beneficial effect of this drug for this patient?
A.
Activation of alpha-2 adrenergic receptors
B.
Inhibition of norepinephrine transporters
C.
Increased release of dopamine and norepinephrine
D.
Inhibition of monoamine oxidases
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