Phar 642 - Principles of Drug Action » Spring 2022 » iRat 09

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Question #1
What medication is classified as a proton pump inhibitor (PPI)?
A.   Esomeprazole
B.   Meclicizine
C.   Calcium Carbonate
D.   Famotidine
Question #2
What is an example of an antacid that produces its effects by directly neutralizing gastric acid?
A.   Nizatidine
B.   Rabeprazole
C.   Calcium carbonate
D.   Scopolamine
Question #3
What is the most likely effect of activation of H2 receptors in gastric acid secreting cells?
A.   Decreased intracellular calcium
B.   Increased cAMP
C.   Decreased cAMP
D.   Increased intracellular calcium
Question #4
What medication is likely to cause accumulation of drugs metabolized by the P450 system?
A.   Famotidine
B.   Magnesium Hydroxide
C.   Cimetidine
D.   Nizatidine
Question #5
What medication is most likely to cause dark/tarry stools and a black/purple tongue?
A.   Bismuth
B.   Misoprostol
C.   Loperamide
D.   Bisacodyl
Question #6
What class of antiemetic produces its beneficial effects by interfering with signals from the vestibulocochlear nerve?
A.   NKI antagonists
B.   D2 antagonists
C.   5-HT3 antagonists
D.   M1 antagonists
Question #7
What neurotransmitter is released from enterochromaffin cells to activate receptors in the enteric nervous system that initiate a peristaltic reflex in response to a bolus in the small intestine?
A.   5HT
B.   Substance P
C.   Acetylcholine
D.   Histamine
Question #8
What would be the overall effect of increasing the osmolarity inside the intestinal lumen?
A.   Increased water absorption
B.   Decreased motility
C.   Increased motility
D.   Increased glucose absorption
Question #9
What drug is most likely to increase the concentration of chloride in the intestinal lumen?
A.   Lubiprostone
B.   Somatostatin
C.   Histamine
D.   Misoprostol
Question #10
What opi0id interacts with mu receptors in the gastrointestinal tract to alleviate diarrhea, but does not cross the blood brain barrier?
A.   Codeine
B.   Loperamide
C.   Morphine
D.   Methylnaltrexone

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