Biology 476 - Topics in Stem Cell Research » Fall 2022 » Types and Sources of Stem Cells

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Question #1
Often during IVF, more blastocysts are generated than can be implanted at once. These extra blastocysts can be frozen down. With the couple's consent, they can be used for what?
A.   For donation to another couple trying to have a baby.
B.   all of these
C.   For production of embryonic stem cells.
D.   For implantation later on, if the couple decides to have another baby.
Question #2
Mouse embryonic stem (ES) cells
A.   come from the inner cell mass of early embryos.
B.   can only be grown in the laboratory.
C.   can be made in the lab from human iPS cells.
D.   can give rise to all tissues and cell types in the body except germ cells.
Question #3
Pluripotent stem cells can be obtained from:
A.   blastocysts generated during IVF
B.   all of these
C.   adult bone marrow
D.   miscarried embryos
Question #4
Name two defining features of stem cells
A.   Mitosis
B.   Self renewal and Unspecialized cells which can specialize
C.   Meiosis
D.   Meiosis and proliferation
Question #5
Cell differentiation always involves
A.   the production of tissue-specific proteins, such as muscle actin.
B.   the movement of cells.
C.   the selective loss of certain genes from the genome.
D.   the cell's sensitivity to environmental cues, such as light or heat.
E.   the transcription of the myoD gene.
Question #6
What is the role of stem cells with regard to the function of adult tissues and organs?
A.   Stem cells are undifferentiated cells that divide asymmetrically, giving rise to one daughter that remains a stem cell and one daughter that will differentiate to replace damaged and worn out cells in the adult tissue or organ.
B.   Stem cells are differentiated cells that have yet to express the genes and proteins characteristic of their differentiated state, and do so when needed for repair of tissues and organs.
C.   Stem cells are determined cells that reside in fully differentiated tissues and can, when needed, differentiate to supply new cells for growth of the tissue.
D.   Stem cells are embryonic cells that persist in the adult, and can give rise to all of the cell types in the body.
E.   Stem cells are fully differentiated cells that reside under the surface of epithelia, in position to take over the function of the tissue when the overlying cells become damaged or worn out.
Question #7
The manipulation of stem cell culture conditions to induce differentiation into a particular cell type.
A.   Inner cell mass (ICM)
B.   Transdifferentiation
C.   Bone marrow stromal cells
D.   Directed differentiation
E.   Parthenogenesis
Question #8
Neural stem cells from the brain can differentiate into which types of cell?
A.   Specialized brain cells and specialized skin cells
B.   Only specialized blood cells
C.   All types of specialized cells
D.   Only specialized brain cells
Question #9
What is a stem cell?
A.   An unspecialized cell with the ability to create specialized cells
B.   A cell only found in the stem of plants.
C.   A specialized cell who can only generate cells of the same type
Question #10
All of the following are true of adult stem cells EXCEPT
A.   they are also called somatic stem cells.
B.   they have the ability to differentiate into every kind of cell in the human body.
C.   they are found in many different tissue types.
D.   scientists are unsure where they reside in most tissues.
Question #11
Pluripotent cells cannot make extra-embryonic tissues such as the amnion, chorion, and other components of the placenta.
A.   False
B.   True
Question #12
Mouse embryonic stem (ES) cells
A.   can be made in the lab from human iPS cells.
B.   can give rise to all tissues and cell types in the body except germ cells.
C.   can only be grown in the laboratory.
D.   come from the inner cell mass of early embryos.
Question #13
An adult hemopoietic stem cell found in the bone marrow
A.   will express all the same transcription factors as those found in an unfertilized egg.
B.   can undergo self-renewing divisions for the lifetime of a healthy animal.
C.   can produce only red blood cells.
D.   will occasionally produce epidermal cells when necessary.
Question #14
What is the developmental pathway by which the hematopoietic stem cell gives rise to a macrophage?
A.   the hematopoietic stem cell must first generate a cell of the myeloid lineage (as opposed to the lymphoid lineage), then a granulocyte/macrophage progenitor, then a monocyte, and finally a macrophage.
B.   the hematopoietic stem cell can give rise to either a lymphoid progenitor or a myeloid progenitor; the myeloid progenitor differentiates directly into a macrophage.
C.   The hematopoietic stem cell can follow two paths, one called lymphoid and the other called myeloid, either of which can ultimately give rise to macrophages and other cell types such as osteoclasts and T cells.
D.   The hematopoietic stem cell gives rise to a variety of cells referred to as granulocytes, any one of which can differentiate further into a macrophage.
E.   the hematopoietic stem cell divides, giving rise to a daughter cell that remains a stem cell and a daughter cell that differentiates directly into a macrophage.
Question #15
Which of the following is NOT true of the Blastocyst stage of development (5-day)
A.   Embryo does not yet necessarily represent a unique individual (twins can form up to 14 days).
B.   all of these are TRUE of the blastocyst stage of development
C.   Not possible to predict whether embryo will be able to develop to term.
D.   Many cells will not form new human, but will give rise to extraembryonic tissue such as placenta which support pregnancy.
E.   Body plan not yet apparent at this stage of development.
Question #16
Which of the following is NOT true of terminally differentiated cells?
A.   have appropriate organelles and proteins which enable them to carry out functions required for a particular tissue
B.   have restricted proliferative capacity
C.   are fully mature cells
D.   are multipotent
E.   all of these are TRUE of terminally differentiated cells
Question #17
An adult hemopoietic stem cell found in the bone marrow
A.   will occasionally produce epidermal cells when necessary.
B.   can produce only red blood cells.
C.   will express all the same transcription factors as those found in an unfertilized egg.
D.   can undergo self-renewing divisions for the lifetime of a healthy animal.
Question #18
There are approximately 50 ____ stem cells in a day 5 blastocyst.
A.   impotent
B.   none of these are correct
C.   pluripotent
D.   totipotent
E.   multipotent

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