HSCI 488 - Epidemiology: Introduction to the Study of Diseases » 2019 » Exam 1

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Question #1
In contrast to present time, the three most common causes of death in the USA in 1900 were … (choose one best answer)
A.   unintentional injuries, liver disease, and cancer
B.   diabetes, stroke, and suicide
C.   pneumonia, tuberculosis, and diarrhea and enteritis
D.   heart disease, cancer, and stroke
Question #2
Breast cancer screening is an example of secondary prevention:
A.   FALSE
B.   TRUE
Question #3
Zika is a disease caused by a virus that spreads to people mostly from the bites of a special type of mosquito, Aedes mosquito (Links to an external site.)Links to an external site..  Such transmission is an example of (choose one best answer):
A.   direct transmission by common vehicle
B.   direct transmission by person-to-person contact
C.   indirect transmission by common vehicle
D.   indirect transmission by vector
Question #4
In nineteenth century London, Dr. John Snow, different from Registrar General William Farr, believed... (choose one best answer)
A.   in the cloud theory over the contaminated water theory.
B.   in the miasmatic theory of disease over the contaminated water theory.
C.   in the low elevation theory over the contaminated water theory.
D.   in the contaminated water theory of disease over the miasmatic theory.
Question #5
Edward Jenner was an important historical figure in epidemiology for his research on cholera vaccination (choose one best answer).
A.   false for vaccination, true for cholera
B.   true for vaccination, false for cholera
C.   false for vaccination, false for cholera
D.   true for vaccination, true for cholera
Question #6
The occurrence of a disease clearly in excess of normal expectancy on several continent or worldwide is referred to as: (choose one best answer)
A.   Endemic disease
B.   Epidemic disease
C.   Epizootic disease
D.   Pandemic disease
E.   Panzootic disease
Question #7
Which conditions must be met for herd immunity to exist? (choose one best answer)
A.   single host species, infection induces partial immunity, multiple means of transmission (i.e., indirect and direct).
B.   single host species, infection induces solid immunity, relatively direct transmission.
C.   multiple animal species and human hosts, infection induces solid immunity, multiple means of transmission (i.e., indirect and direct).
D.   multiple animal species and human hosts, infection induces partial immunity, relatively direct transmission.
Question #8
One way in which sequential and simultaneous testing differ is that... (choose one best answer)
A.   simultaneous testing uses one test first then recalls those who test positive for a second test, whereas sequential testing screens the entire population with two tests.
B.   sequential testing results in gain in the net sensitivity and the net specificity whereas simultaneous testing results in loss in the net sensitivity and the net specificity.
C.   sequential testing results in gain in the net specificity but loss in the net sensitivity whereas simultaneous testing results in loss in the net specificity but gain in the net sensitivity
D.   sequential testing uses two very expensive tests whereas simultaneous testing uses one inexpensive test and one very expensive test.
Question #9
Disease is a result of interaction between the host, the vector and the environment. (mark as True or False)
A.   FALSE
B.   TRUE
Question #10
During a foodborne outbreak the illness is transmitted through … (choose one best answer)
A.   Direct transmission via common vehicle exposure
B.   Indirect transmission via common vehicle exposure
C.   Indirect transmission via common vector
D.   Direct transmission via common vector
Question #11
A cohort consisted of 1,921,260 individuals, of whom during initial examination 1,887,060 did not have diabetes and 34,200 had type 2 diabetes. What type of measure of disease occurence can be calculated using information described above. (choose one best answer)
A.   Prevalence
B.   Risk
C.   Incidence
D.   Rate
Question #12
A cohort consisted of 1,921,260 individuals, of whom during initial examination 1,887,060 did not have diabetes and 34,200 had type 2 diabetes. Calculate appropriate measure of disease occurence using information described above. Use multiplier 1,000. Show calculations for credit.
A.   34,200/1,921,260* 1,000= 17.8 per thousand.
Question #13
Calculate the risk of illness (attack rates) among persons who ate each food item, i.e. potato salad, tuna salad and chicken wrap. Use 100 multiplier (i.e. present the result as a percentage). Show calculations for credit.
A.   Tuna Salad: 135/150*100= 90% attack rate Potato Salad: 130/220*100= 59% attack rate Chicken Wrap: 136/190*100= 71% attack rate
Question #14
Which one of the food items from the previous question (potato salad, tuna salad or chicken wrap) is more likely responsible for the outbreak of gastroenteritis in this population and why?
A.   Tuna Salad
Question #15
Calculate the case-fatality (CF) rate for Ebola outbreak in Zaire in 2014-2016. Use multiplier 100 (i.e. present the result as a percentage). Show all calculations for credit.
A.   2,543/3,811*100= 66.7% CF rate
Question #16
In 1949 one of the most important cohort studies was started, the Framingham study. 5,000 residents were enrolled into the study. At the initial examination 80 of 5,000 were identified as having heart disease. Are cases described above incident or prevalent cases?
A.   Prevalent
B.   Incident
Question #17
In 1949 one of the most important cohort studies was started, the Framingham study. 5,000 residents were enrolled into the study. At the initial examination 80 of 5,000 were identified as having heart disease. Calculate the measure of disease occurence that can be derived from the presented data based on your answer on the previous question. Use multiplier 1,000. Show calculations for credit.
A.   16
Question #18
Why the measure of disease occurence calculated above is important (at least one reason)?
A.   Because it allows us to see the number of cases of disease present in a specific time.
Question #19
In 1949 one of the most important cohort studies was started, the Framingham study. 5,000 residents were enrolled into the study. At the initial examination 80 of 5,000 were identified as having heart disease. After the initial examination eligible subjects of the Framingham study were followed for 5 years to determine the frequency of the development of heart disease: 220 of these subjects developed heart disease over this time period. Are the 220 cases described above incident or prevalent cases?
A.   Prevalent
B.   Incident
Question #20
In 1949 one of the most important cohort studies was started, the Framingham study. 5,000 residents were enrolled into the study. At the initial examination 80 of 5,000 were identified as having heart disease. After the initial examination eligible subjects of the Framingham study were followed for 5 years to determine the frequency of the development of heart disease: 220 of these subjects developed heart disease over this time period. Calculate the measure of disease occurence based on your answer on the previous question. Use multiplier 10,000. Show calculations for credit.
A.   220/5,000*10,000=440 per 10,000
Question #21
Why the measure of disease occurence calculated above is important (at least one reason)?
A.   Because it's used to describe how often the disease occurs in a population.
Question #22
Total number of deaths from all causes in a town X with population 300,000 was 260. There were also 240 cases of a disease Q observed. 24 died of a disease Q. Calculate mortality ratio in this population. Use multiplier 10,000. Show calculations for credit.
A.   260/300,00=8.6 per 10,000
Question #23
The screening test in laboratory has 98% sensitivity and 99% specificity. In real world test results could not be replicated. Can this test considered to be reliable? (Circle one best answer)
A.   No
B.   Yes
Question #24
Percent agreement between two or more observers is the first step in calculation of kappa statistics and represents observed percent agreement. (Mark as True or False)
A.   FALSE
B.   TRUE
Question #25
Kappa Statistic measures… (choose one best answer)
A.   To what extend does the agreement between the two observers exceed the level of agreement that would results from chance
B.   To what extend does the agreement between the two readings of the same observer exceed the level of agreement that would results from chance alone
C.   To what extend does the disagreement between the two observers exceed the level of agreement that would results from chance
D.   The percentage of patients’ test results that they agree on
E.   The percentage of patients’ test results that they disagree on
Question #26
You are given information about the number of people in each of the age categories in populations A and B and the total number of deaths in each population. In addition, you are given the number of people and the number of deaths in each of the age categories in the standard population. What type of adjustment of death rates should be performed given information in the table below? (Choose the best answer)
A.   Indirect adjustment of mortality rates by age
B.   Indirect adjustment of mortality rates by age and sex
C.   Direct adjustment of mortality rates by age
D.   Direct adjustment of mortality rates by age and sex
Question #27
Intrasubject variability refers to variation in reading test results by different readers. (Mark as True or False)
A.   FALSE
B.   TRUE
Question #28
Standardized mortality ratio (SMR) is used to compare mortality rates in two or more populations using indirect adjustment of rates? (Mark as True or False)
A.   TRUE
B.   FALSE
Question #29
You are given information about the number of people and the number of deaths in each of the age categories in populations A and B. You also have the standard population and the number of people in each of the age categories in it. What type of adjustment of rates can be performed given information above? (Choose the best answer)
A.   Indirect adjustment of mortality rates by age
B.   Direct adjustment of mortality rates by age and sex
C.   Indirect adjustment of mortality rates by age and sex
D.   Direct adjustment of mortality rates by age
E.   Neither direct not indirect adjustment of rates
Question #30
If sensitivity and specificity of the test remain unchanged what will happen with PPV and NPV if the prevalence of the disease increases?
A.   Both PPV and NPV will remain unchanged
B.   The PPV will remain unchanged and NPV will decrease
C.   The PPV will decrease and NPV will increase
D.   The PPV will increase and NPV will decrease
E.   The PPV will increase and NPV will remain unchanged
Question #31
The broader definition of epidemiology is “the study of the distribution and determinants of health-related states or events in specified populations and...” (choose one best answer),,
A.   the use of this information to cure medical problems.
B.   the application of this study to control of health problems.
C.   the transfer of this knowledge to preventive programs.
D.   the employment of such findings to preventive and curative programs.

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