HSCI 336 - Health Aspects of Drug Use » Summer 2020 » Quiz 5

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Question #1
Which of the following terms is defined as the dosage difference between an acceptable level of effectiveness and the lowest toxic dose?
A.   Drug potency
B.   Therapeutic index
C.   Safety margin
D.   Cumulative effect
Question #2
When neither the person taking the drug nor the person evaluating the effects of the drug knows which people are getting the experimental drug and which people are getting the placebo, this procedure is referred to as a(n) ________.
A.   preclinical study
B.   effect size
C.   double-blind procedure
D.   design flaw
Question #3
Most of our drugs originally came either directly or indirectly from
A.   plants.
B.   South America.
C.   petroleum.
D.   German chemists.
Question #4
With increasing doses of any useful drug, there is usually an increase in the number and severity of
A.   side effects.
B.   placebo effects.
C.   effects on the stomach.
D.   beneficial effects.
Question #5
The potency of a drug is defined in terms of
A.   whether it has a detectible odor.
B.   its dependence potential.
C.   the amount required to produce an effect.
D.   the magnitude of the effect it produces.
Question #6
The time course of a drug's action depends on
A.   how the drug is eliminated from the body.
B.   how the drug is administered.
C.   how rapidly the drug is absorbed.
D.   all of the above.
Question #7
Regardless of the route of administration, psychoactive drugs reach the brain tissue by way of the
A.   spinal cord.
B.   bloodstream.
C.   liver.
D.   meninges.
Question #8
After oral administration, most absorption of the drug molecules takes place in the
A.   small intestine.
B.   lower bowel.
C.   kidneys.
D.   heart.
Question #9
Of the following routes of administration, which will produce fastest onset of effects?
A.   using a rectal suppository.
B.   inhalation.
C.   rubbing it on the head.
D.   intramuscular injection.
Question #10
Alcohol has a low tendency, but THC has a high tendency, to
A.   produce dependence.
B.   bind to the serotonin receptor.
C.   dissolve in water.
D.   bind to blood proteins.
Question #11
The blood-brain barrier
A.   is fully developed in humans when they are born.
B.   prevents many drugs from entering the brain.
C.   is designed to allow all drug compounds into the brain.
D.   cannot be penetrated, even with trauma to the brain.
Question #12
Concussions and cerebral infections can decrease the effectiveness of
A.   the blood-brain barrier.
B.   protein binding.
C.   drug metabolism.
D.   multiple drug doses.
Question #13
The most common way for drug molecules to be deactivated is by
A.   elimination through the bowel.
B.   reuptake.
C.   protein binding.
D.   the action of CYP450 enzymes in the liver.
Question #14
When use of a drug interferes with normal behavior, experienced users may learn to compensate and show less impairment than new users. This is an example of
A.   an active metabolite.
B.   a prodrug.
C.   behavioral tolerance.
D.   drug disposition tolerance.
Question #15
Which of the following would be a reason for a drug company NOT to pursue expensive clinical trails with a new drug?
A.   The therapeutic index is greater than 1.
B.   The therapeutic index less than 1.
C.   The drug produces no side effects.
D.   The drug produces side effects.
Question #16
The group of psychoactive drugs called stimulants includes
A.   heroin.
B.   Prozac.
C.   cocaine.
D.   LSD.
Question #17
Among the psychoactive drugs, alcohol can be classified as a(n)
A.   depressant.
B.   stimulant.
C.   hallucinogen.
D.   opioid.
Question #18
________ are a group of analgesic (painkilling) drugs that produce a relaxed, dreamlike state; moderately high doses often induce sleep.
A.   Opioids
B.   Antidepressants
C.   Antipsychotics
D.   Hallucinogens
Question #19
Among the psychoactive drugs, alcohol can be classified as a(n) ________.
A.   stimulant
B.   depressant
C.   opioid
D.   hallucinogen
Question #20
The group of psychoactive drugs called stimulants includes:
A.   heroin.
B.   LSD.
C.   Prozac.
D.   cocaine.
Question #21
The threshold on a dose-response curve is the
A.   lowest dose at which there is an observable effect of the drug.
B.   therapeutic index of the drug.
C.   safe effective dose of the drug.
D.   point at which the dose of the drug causes maximal response.

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