HSCI 336 - Health Aspects of Drug Use » Summer 2020 » Quiz 5

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Question #1
Which of the following terms is defined as the dosage difference between an acceptable level of effectiveness and the lowest toxic dose?
A.   Drug potency
B.   Cumulative effect
C.   Therapeutic index
D.   Safety margin
Question #2
When neither the person taking the drug nor the person evaluating the effects of the drug knows which people are getting the experimental drug and which people are getting the placebo, this procedure is referred to as a(n) ________.
A.   double-blind procedure
B.   design flaw
C.   preclinical study
D.   effect size
Question #3
Most of our drugs originally came either directly or indirectly from
A.   plants.
B.   German chemists.
C.   South America.
D.   petroleum.
Question #4
With increasing doses of any useful drug, there is usually an increase in the number and severity of
A.   effects on the stomach.
B.   side effects.
C.   beneficial effects.
D.   placebo effects.
Question #5
The potency of a drug is defined in terms of
A.   the magnitude of the effect it produces.
B.   whether it has a detectible odor.
C.   its dependence potential.
D.   the amount required to produce an effect.
Question #6
The time course of a drug's action depends on
A.   how the drug is eliminated from the body.
B.   how rapidly the drug is absorbed.
C.   how the drug is administered.
D.   all of the above.
Question #7
Regardless of the route of administration, psychoactive drugs reach the brain tissue by way of the
A.   meninges.
B.   bloodstream.
C.   spinal cord.
D.   liver.
Question #8
After oral administration, most absorption of the drug molecules takes place in the
A.   small intestine.
B.   kidneys.
C.   heart.
D.   lower bowel.
Question #9
Of the following routes of administration, which will produce fastest onset of effects?
A.   inhalation.
B.   rubbing it on the head.
C.   using a rectal suppository.
D.   intramuscular injection.
Question #10
Alcohol has a low tendency, but THC has a high tendency, to
A.   produce dependence.
B.   bind to the serotonin receptor.
C.   bind to blood proteins.
D.   dissolve in water.
Question #11
The blood-brain barrier
A.   prevents many drugs from entering the brain.
B.   is fully developed in humans when they are born.
C.   cannot be penetrated, even with trauma to the brain.
D.   is designed to allow all drug compounds into the brain.
Question #12
Concussions and cerebral infections can decrease the effectiveness of
A.   the blood-brain barrier.
B.   multiple drug doses.
C.   protein binding.
D.   drug metabolism.
Question #13
The most common way for drug molecules to be deactivated is by
A.   reuptake.
B.   protein binding.
C.   the action of CYP450 enzymes in the liver.
D.   elimination through the bowel.
Question #14
When use of a drug interferes with normal behavior, experienced users may learn to compensate and show less impairment than new users. This is an example of
A.   a prodrug.
B.   an active metabolite.
C.   drug disposition tolerance.
D.   behavioral tolerance.
Question #15
Which of the following would be a reason for a drug company NOT to pursue expensive clinical trails with a new drug?
A.   The therapeutic index is greater than 1.
B.   The therapeutic index less than 1.
C.   The drug produces side effects.
D.   The drug produces no side effects.
Question #16
The group of psychoactive drugs called stimulants includes
A.   heroin.
B.   cocaine.
C.   LSD.
D.   Prozac.
Question #17
Among the psychoactive drugs, alcohol can be classified as a(n)
A.   stimulant.
B.   depressant.
C.   opioid.
D.   hallucinogen.
Question #18
________ are a group of analgesic (painkilling) drugs that produce a relaxed, dreamlike state; moderately high doses often induce sleep.
A.   Antipsychotics
B.   Antidepressants
C.   Hallucinogens
D.   Opioids
Question #19
Among the psychoactive drugs, alcohol can be classified as a(n) ________.
A.   opioid
B.   hallucinogen
C.   stimulant
D.   depressant
Question #20
The group of psychoactive drugs called stimulants includes:
A.   Prozac.
B.   cocaine.
C.   LSD.
D.   heroin.
Question #21
The threshold on a dose-response curve is the
A.   point at which the dose of the drug causes maximal response.
B.   therapeutic index of the drug.
C.   lowest dose at which there is an observable effect of the drug.
D.   safe effective dose of the drug.

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